Recreational physical activity is associated with reduced breast cancer risk in adult women at high risk for breast cancer: A cohort study of women selected for familial and genetic risk

RD Kehm; JM Genkinger; RJ MacInnis; EM John; KA Phillips; GS Dite; RL Milne; N Zeinomar; Y Liao; JA Knight; MC Southey; WK Chung; GG Giles; SA McLachlan; KD Whitaker; M Friedlander; PC Weideman; G Glendon; S Nesci; K Investigators; IL Andrulis; SS Buys; MB Daly; JL Hopper; MB Terry

Journal article

Recreational physical activity is associated with reduced breast cancer risk in adult women at high risk for breast cancer: A cohort study of women selected for familial and genetic risk

RD Kehm, JM Genkinger, RJ MacInnis, EM John, KA Phillips, GS Dite, RL Milne, N Zeinomar, Y Liao, JA Knight, MC Southey, WK Chung, GG Giles, SA McLachlan, KD Whitaker, M Friedlander, PC Weideman, G Glendon, S Nesci, K Investigators Show all

Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2020

DOI: 10.1158/0008-5472.CAN-19-1847

Abstract

Although physical activity is associated with lower breast cancer risk for average-risk women, it is not known if this association applies to women at high familial/genetic risk. We examined the association of recreational physical activity (self-reported by questionnaire) with breast cancer risk using the Prospective Family Study Cohort, which is enriched with women who have a breast cancer family history (N ¼ 15,550). We examined associations of adult and adolescent recreational physical activity (quintiles of age-adjusted total metabolic equivalents per week) with breast cancer risk using multivariable Cox proportional hazards regression, adjusted for demographics, lifestyle factors, and ..

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University of Melbourne Researchers

Robert MacInnis Author

Kelly Phillips Author

Gillian Dite Author

Roger Milne Author

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Grants

Awarded by National Institutes of Health

Funding Acknowledgements

The six sites of the BCFR were supported by grant U01 CA164920 from the USA NCI. This work was also supported by grants to kConFab and the kConFab Follow-Up Study from Cancer Australia (grant numbers 809195 and 1100868), the Australian National Breast Cancer Foundation (grant number IF 17 kConFab), the National Health and Medical Research Council (grant numbers 454508, 288704, and 145684), the NIH USA (grant number 1R01CA159868), the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia (grant numbers not applicable). R.D. Kehm is supported by the NIH, NCI, Cancer Epidemiology Training Grant (grant number T32-CA009529). K.-A. Phillips is an Australian National Breast Cancer Foundation Practitioner Fellow. J.L. Hopper and M.C. Southey are National Health and Medical Research Council Senior Principal and Senior Research Fellows, respectively.